Dr. John Falcone

Dr. John Falcone is a Weill Cornell-trained Endocrinologist with the highest caliber medical education, training, board certifications and specialization for disorders and conditions of the endocrine system. With an approach of maintaining health through prevention, Dr. Falcone places an emphasis on comprehensive care that focuses on treating a patient as a whole person.

Academic Background

Research Fellowship, Weill Cornell Medical Center, New York, NY
Fellowship in Endocrinology, Diabetes and Metabolism, New York Presbyterian/Weill Cornell Medical Center, Memorial Sloan Kettering Cancer Center, and Hospital for Special Surgery, New York, NY
Residency in Internal Medicine, New York Presbyterian/Weill Cornell Medical Center, New York, NY
M.D. Drexel University College of Medicine, Philadelphia, PA
B.S. Drexel University, Philadelphia, PA

Board Certifications

Dr. Falcone holds board certifications from the American Board of Internal Medicine in:

Internal Medicine
Endocrinology, Diabetes and Metabolism

Professional Memberships

American Association of Clinical Endocrinologists
American College of Physicians
American Society of Andrology
Endocrine Society

Medical Society of the State of New York
National Lipid Association
New York County Medical Society

Hospital Privileges

New York Presbyterian Hospital, New York, NY
Assistant Attending Physician

Weill Cornell Medical College, New York, NY
Clinical Instructor of Medicine

Get to Know Dr. John Falcone

What Made You Focus on Endocrinology?

Hormones, being the ultimate chemical messengers, regulate virtually every process in the human body via their sophisticated control systems. This offers the field of Endocrinology a unique perspective that cuts across all other medical specialties. While this initially caught my interest in Endocrinology, what truly sparked my passion are the strong longitudinal patient relationships that are forged by working in this specialty. Being an Endocrinologist, I am afforded the opportunity to build deep, long-term bonds with my patients, seeing them through years of management and life changes. Through these interactions, I can profoundly and measurably improve my patients' quality of life over time. In many diseases of the Endocrine system, a patient’s daily decisions are critical. Endocrinology places a special focus on patient education and self-management. As a physician who recognizes the importance of teaching, this specialty allows me the highly rewarding role of educator and coach to equip my patients with the knowledge and skills they need to master their health. Additionally, there is a certain excitement in Endocrinology as a rapidly evolving field where the science is constantly advancing. New and cutting edge diagnostics, medications, and technologies offer stimulating opportunities to improve patient care with innovative treatments.

What Is Your Approach to Medicine?

My mission is to deliver compassionate, high-quality care that is not only focused on treating a condition, but also getting to know who my patient is as a person, and what they have experienced that has brought them to see me. I believe it is essential to take the time to ensure that my patient understands all aspects of their diagnosis and prescribed treatment plan. An additional foundation of my practice is the utilization of best available research-based medicine to evaluate and treat my patients. The rapidly evolving specialty of Endocrinology underscores the importance of being up to date on the latest advancements in the field and translating that into clinical practice to offer the best care to my patients.

Publications

Taylor SR, Falcone JN, Cantley LC, Goncalves MD. Developing dietary interventions as therapy for cancer. Nat Rev Cancer, 22: 452-466. 2022 August.
Blow, T, Hyde PN, Falcone JN, Neinstein A, Vasan N, Chitkara R, Hurd MA, Sardesai S, Lustberg MB, Flory JH, Volek JS, Goncalves MD. Treating alpelisib-induced hyperglycemia with very low carbohydrate diets and sodium-glucose co transporter 2 inhibitors: a case series. Integr Cancer Ther, 20:1-6, 2021 July.
Falcone JN, Hurd MA, Kumar S, Yeung M, Newberry C, So MY, Dakin G, Bellorin-Marin O, Afaneh C, Hudgins L, Pena J, Goncalves MD. The ratio of unsaturated to saturated fatty acids is a distinguishing feature of NAFLD in subjects with metabolic disease. JES, 5: A421, 2021 May.
Falcone JN, Dobri, G. Management of the Patient with Prolactinoma during Pregnancy. Pituitary Through the Lifecycle, edited by Susan L. Samson and Adriana Ioachimescu, Springer, 2022.
Boucai L, Falcone J, Coombs C, Zehir A, Berger M, Levine R, Fagin, J. Radioactive iodine-related clonal hematopoiesis in advanced thyroid cancer patients is common and associated with adverse clinical outcomes. JCEM, 103(11): 4216- 4223, 2018. Nov.
Kong J, Whelan K, Dang B, Caro-Monroi A, Soroush A, Falcone J, Amaravadi R, Rustgi A, Ginsberg G, Falk G, Nakagawa H, Lynch J. Autophagy levels are elevated in Barrett’s esophagus and promote cell survival from acid and oxidative stress. Molecular Carcinogenesis, 55(11): 1526-1541, 2016 Nov.
Ferrer CM, Lynch TP, Sodi V, Falcone JN, Schwab L, Peacock D, Vocadlo DJ, Seagroves TN, Reginato MJ. O-GlycNAcylation regulates cancer metabolism and survival stress signaling via upregulation of HIF-1 pathway. Molecular Cell, 54(5): 820-831, 2014 June.

Medical Talks & Presentations

Falcone J. Developing Precision Medicine for Diabetes and Metabolic Disease. Presented at New York Presbyterian/ Weill Cornell Medicine Endocrinology Grand Rounds, 2022 April.
Falcone J. Thyroid Awareness Month: Learn More About Your Metabolic Gatekeeper. Presented at Weill Cornell Medicine Clinical & Translational Science Center Community Interactive Videoconferencing Program; 2022 Jan.
Falcone J. Next Generation Sequencing for Diabetes and Metabolic Disease. Presented at New York Presbyterian/ Weill Cornell Medicine Endocrinology Grand Rounds, 2021 May.
Falcone JN, Hurd MA, Kumar S, Yeung M, Newberry C, So MY, Dakin G, Bellorin-Marin O, Afaneh C, Hudgins L, Pena J, Goncalves MD. The ratio of unsaturated to saturated fatty acids is a distinguishing feature of NAFLD in subjects with metabolic disease. Poster presented at: Endocrine Society Annual Meeting; March 20-23, 2021; virtual.
Falcone J. Diabetes Mellitus: Beyond Types 1 and 2. Presented at New York Presbyterian/ Weill Cornell Medicine Endocrinology Grand Rounds, 2020 May.
Falcone J. The Tired Adrenal Dilemma: A Physician’s Guide to Understanding and Addressing Patients Interested in Alternative Medicine. Presented at New York Presbyterian/ Weill Cornell Medical Center Internal Medicine Senior Seminar, 2018 Sept.
Falcone J, Mendelsohn Curanaj F, Jeffrie Seley J, Sinha Gregory N. Glucose- The Next Vital Sign: An Educational Intervention to Improve Glycemic Control on Medicine Units at NYP/WC. Presented at the New York Presbyterian Weill Cornell Medical Center Quality Improvement/ Patient Safety Poster Session, 2018 May.
Mendelsohn Curanaj F, Seley JJ, Falcone J, Barenbaum S, Alamri N, Askin G, Braunstein R, Jannat-Khah DP, Kachnowski T, Lu A, Sinha A, Kim R. Standardizing and Streamlining DKA Guidelines in the Weill Cornell Medical ICU and the Lower Manhattan Hospital ICU. Presented at the New York Presbyterian/ Weill Cornell Medical Center Quality Improvement/ Patient Safety Poster Session, 2018 May.
Falcone J, Whelan K, Rustgi A, Lynch J, Nakagawa H. Metformin Reduces Oxidative Stress and Mitochondrial Dysfunction Induced by Hyperglycemic Conditions in Cell Models of Barrett’s Esophagus and Esophageal Adenocarcinoma. Presented at the Latino Medical Student Association Northeast Regional Conference at Weill Cornell Medical College, 2014 March.
Falcone J, Whelan K, Rustgi A, Lynch J, Nakagawa H. Metformin Reduces Oxidative Stress and Mitochondrial Dysfunction Induced by Hyperglycemic Conditions in Cell Models of Barrett’s Esophagus and Esophageal Adenocarcinoma. Presented at Drexel University College of Medicine Discover Day, 2013 Oct.
Falcone J, Whelan K, Rustgi A, Lynch J, Nakagawa H. Metformin Reduces Oxidative Stress and Mitochondrial Dysfunction Induced by Hyperglycemic Conditions in Cell Models of Barrett’s Esophagus and Esophageal Adenocarcinoma. Presented at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Medical Student Research Fellowship Symposium at Vanderbilt University, 2013 Aug.
Falcone J, Ferrer CM, Lynch TJ, Reginato MJ. The Role of O-GlcNAc Transferase in Enhancing Breast Cancer Metabolism via Upregulation of the mTOR/HIF-1 Pathway. Presented at Drexel University College of Medicine Medical Student Research Day, 2013 March.